| Main Title |
Effects of Postnatal Trimethyltin or Triethyltin Treatment of CNS Catecholamine, GABA (Gamma-Aminobutyric Acid), and Acetylcholine Systems in the Rat. |
| Author |
Mailman, R. B. ;
Krigman, M. R. ;
Frye, G. D. ;
Hanin, I. ;
|
| CORP Author |
North Carolina Univ. at Chapel Hill. School of Medicine. ;Pittsburgh Univ., PA. School of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1983 |
| Report Number |
EPA-R-809644; EPA/600/J-83/310; |
| Stock Number |
PB86-117223 |
| Additional Subjects |
Tin ;
Toxicity ;
Brain ;
Rats ;
Neurochemistry ;
Damage ;
Hippocampus ;
Ammino compounds ;
Butyric acid ;
Metabolism ;
Behavior ;
Reprints ;
Trimethyltin sulfate ;
Trimethyltin hydroxide ;
Dopamine
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-117223 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
The effects on brain neurochemistry of two neurotoxic tin compounds, trimethyltin (TMT) hydroxide and triethyltin (TET) sulfate, were examined. Long-Evans rats were treated with TMT hydroxide (1 mg/kg, i.p.) on alternate days from day 2 to 29 of life. These treatments caused a weight deficit of 10-20% by the time the animals were killed on day 55 by head-focused microwave irradiation. These TMT treatments are known to cause severe neuronal loss in the hippocampus and lesser damage in other brain regions. (Copyright (c) 1983 International Society for Neurochemistry.) |
