Record Display for the EPA National Library Catalog
RECORD NUMBER: 5 OF 8| Main Title | Letter from Socma to Usepa Submitting Information Concerning Tributyl Phosphate When Administered in the Diet of Rats in a 24-month Oncogenicity Study with Attachment. | |||||||||||
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| CORP Author | ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1991 | |||||||||||
| Report Number | 89-910000154 | |||||||||||
| Stock Number | OTS0526409-3 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Tributyl Phosphate ; Chronic Toxicity ; Mammals ; Rats ; Oral ; Diet ; Toxic substances ; Laboratory animals ; CAS No 126-73-8 | |||||||||||
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| Collation | 4p | |||||||||||
| Abstract | Preliminary results from an oncogenicity study in rats revealed subchronic toxic effects of tributyl phosphate (CAS No. 126-73-8). Groups of rats (50/sex/exposure group, strain not reported) were exposed in the diet at concentrations of 0, 200, 700 and 3000 ppm. A single high-dose female rat died on day 43 of the study. Gross necropsy findings included two 0.6 cm calculi in the urinary bladder which was distended with yellow fluid, dilated renal pelvis with multiple embedded white pinpoint foci, an ocular opacity, and dark red lungs. |