||Quantification of Germ-Cell Risk Associated with the Induction of Heritable Translocations.
Dellarco, V. L. ;
Rhomberg, L. R. ;
||Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment.
Germ cells ;
Ethylene oxide ;
Dose-response relationships ;
Risk assessment ;
Species diversity ;
Hereditary diseases ;
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The paper examines how quantitative risk methods might be extended to analyses of risks associated with the induction of heritable translocations in the human germ line. The chemical used in the modeling is ethylene oxide (EtO). It is hoped that this risk analysis will help define key types of data needed to quantify genetic risk, the biological considerations that go into such an analysis, and the inferences that must be drawn from mouse dose-response data when making predictions about human germ-cell risk. (Copyright (c) 1990. Cold Spring Harbor Laboratory Press.)