Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Clastogenicity Evaluation of Seven Chemicals Commonly Found at Hazardous Industrial Waste Sites.
Author Sandhu, S. S. ; Ma, T. H. ; Peng, Y. ; Zhou, X. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Western Illinois Univ., Macomb.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/335;
Stock Number PB90-199456
Additional Subjects Industrial wastes ; Hazardous materials ; Chemical compounds ; Waste disposal ; Public health ; Bioassay ; Site surveys ; Lethal dosage ; Laboratory animals ; Concentration(Composition) ; Genetics ; Toxicity ; Pesticides ; Reprints ; Health hazards ; Clastogenicity ; Biological effects ; Occupational safety and health ; Tradescantia-micronucleus assay ; Land pollution
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
NTIS  PB90-199456 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 08/27/1990
Collation 11p
Seven chemicals commonly found at industrial waste sites were tested with the Tradescantia-micronucleus (Trad-MCN) assay to evaluate their clastogenic potential. They were: Aldrin, arsenic trioxide, 1,2-benz(a,h)anthracene, dieldrin, heptachlor, lead tetraacetate, and tetrachloroethylene. Results of repeated tests for clastogenicity yielded the minimum effective dose (MED) of 0.44 ppm for lead tetraacetate, 3.81 ppm for dieldrin, and 1.88 ppm for heptachlor. Arsenic trioxide and 1,2-benz(a,h)anthracene yielded positive responses at the MED of 3.96 ppm and 2.28 ppm, respectively. Aldrin and tetrachloroethylene were considered to be immiscible with water, and the test yielded negative responses. Results of tetrachloroethylene fume treatment yielded a positive response at the MED of 30 ppm/min in 2-hr exposures. Five chemicals determined to be clastogens by the test were ranked according to their MED in the descending order of potency as follows: Lead tetraacetate, heptachlor, 1,2-benz(a,h)anthracene, dieldrin, and arsenic trioxide. Results of the study indicate that Trad-MCN bioassay could be effectively utilized for assessing the genetic hazard from the leachates and volatile compounds emanating from uncontrolled industrial waste sites. (Copyright (c) 1989 Elsevier Science Publishers B.V. (Biomedical Division.)