||Report of an Animal Experiment to Analyze Silica Gel Dust by Intratracheal and in Traperitoneal Injections in a Rat with Cover Letter dated 07/24/80.
||MCB Manufacturing Chemists, Inc., Cincinnati, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||30 Jul 1980
Silica gel ;
Body weight ;
Laboratory animals ;
Lymph nodes ;
Intramuscular injections ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
The reaction and behavior of rats when injected with silica gel dust are being tested, as opposed to the reaction and behavior of a pure quartz dust application. For the experiment we used female Wistar rats weighing 250g. The animals were nourished with Altronium-R and water ad libitum. The dust originated from a fine dust sample from E. Merck, Darmstadt. The quartz was Doerentruper Nr. 12, sedimented to less than 3 micrograms. Both were suspended in a sterile 0.9 salt solution. The intratrachea injection contained a dust dose of 30mg/animal in 0.5ml salt solution-the intraperitoneum injections 50mg/animal in 1.0ml salt solution.