Record Display for the EPA National Library Catalog


Main Title Report of an Animal Experiment to Analyze Silica Gel Dust by Intratracheal and in Traperitoneal Injections in a Rat with Cover Letter dated 07/24/80.
CORP Author MCB Manufacturing Chemists, Inc., Cincinnati, OH.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 30 Jul 1980
Year Published 1980
Report Number 8HEQ-0780-0354;
Stock Number OTS-0204857
Additional Subjects Silica gel ; Rats ; Trachea ; Dust ; Quartz ; Body weight ; Toxicology ; Pathology ; Dosage ; Silicosis ; Laboratory animals ; Lymph nodes ; Heart ; Liver ; Spleen ; Salts ; Granuloma ; Intramuscular injections ;
Library Call Number Additional Info Location Last
NTIS  OTS-0204857 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 40p
The reaction and behavior of rats when injected with silica gel dust are being tested, as opposed to the reaction and behavior of a pure quartz dust application. For the experiment we used female Wistar rats weighing 250g. The animals were nourished with Altronium-R and water ad libitum. The dust originated from a fine dust sample from E. Merck, Darmstadt. The quartz was Doerentruper Nr. 12, sedimented to less than 3 micrograms. Both were suspended in a sterile 0.9 salt solution. The intratrachea injection contained a dust dose of 30mg/animal in 0.5ml salt solution-the intraperitoneum injections 50mg/animal in 1.0ml salt solution.