"International Life Sciences Institute." Includes bibliographical references and index.

Summary and Recommendations / David A. Neumann and Carole A. Kimmel -- Ch. 1. Accounting for Variability in Responsiveness in Human Health Risk Assessment / Jean A. Grassman, Carole A. Kimmel and David A. Neumann -- Ch. 2. Strategies for Assessing Human Variability in Susceptibility and Using Variability to Infer Human Risks / Dale Hattis -- Ch. 3. Interindividual Variability in Neurotoxicity / David A. Eckerman, John R. Glowa and W. Kent Anger -- Ch. 4. Variability in Human Response to Reproductive and Developmental Toxicity / Anthony R. Scialli and Armand Lione -- Ch. 5. Risk Assessment of the Effects of Ozone Exposure on Respiratory Health: Dealing with Variability in Human Responsiveness to Controlled Exposures / Philip A. Bromberg --Ch. 6. Host-Environment Interactions That Affect Variability in Human Cancer Susceptibility / L.T. Frame, C.B. Ambrosone and F.F. Kadlubar [and others] -- Ch. 7. Genetic Susceptibility and Cancer Risk / Neil Caporaso and Nathaniel Rothman -- Ch. 8. Human Variability in Susceptibility and Response: Implications for Risk Assessment / David A. Neumann and Carole A. Kimmel. This book, a compilation of eight original manuscripts commissioned by the ILSI Risk Science Institute, addresses the increasing awareness that individual biological differences be reflected when assessing human health risks associated with exposure to potential toxicants in the workplace, the home, and the environment. Scientists from academia, industry, and government address the evidence for variability in human response to chemicals associated with reproductive and developmental effects; effects on the nervous system and lungs; and cancer. Their reports convey both the current state of scientific understanding of response variability and the genetic basis for such observations.