| Contents Notes |
1. Harming and Helping through Time: The History of Toxicology / Richard W. Lane and Joseph F. Borzelleca -- 2. Use of Toxicology in the Regulatory Process / Barbara D. Beck, Edward J. Calabrese, Tracey M. Slayton and Ruthann Rudel -- 3. Metabolism: A Determinant of Toxicity / Raymond A. Kemper, Johnnie R. Hayes and Matthew S. Bogdanffy -- 4. Toxicokinetics / Andrew Gordon Renwick -- 5. Physiologically Based Pharmacokinetic and Toxicokinetic Models / Kannan Krishnan and Melvin E. Andersen -- 6. Toxicopanomics: Applications of Genomics, Proteomics, and Metabonomies in Predictive and Mechanistic Toxicology / Don Robertson, Sven Beushausen and William Pennie -- 7. Toxicologic Assessment of Pharmaceutical and Biotechnology Products / Michael A. Dorato, Carl L. McMillian and Mary Jo Vodicnik -- 8. Statistics for Toxicologists / Shayne C. Gad -- 9. Quantitative Extrapolations in Toxicology / Joseph V. Rodricks, David W. Gaylor and Duncan Turnbull -- 10. Practice of Exposure Assessment / Dennis J. Paustenbach and Amy K. Madl -- 11. Epidemiology for Toxicologists / Ralph R. Cook -- 12. Principles of Pathology for Toxicology Studies / Steven R. Frame and Peter C. Mann -- 13. Information Infrastructure of Toxicology / Philip Wexler, Pertti (Bert) Hakkinen, Patricia Nance, Ann Parker and Jacqueline Patterson -- 14. Foodborne Toxicants / Chada S. Reddy and A. Wallace Hayes -- 15. Solvents and Industrial Hygiene / David L. Dahlstrom and Margaret Buckalew -- 16. Crop Protection Chemicals: Mechanism of Action and Hazard Profiles / Charles B. Breckenridge and James T. Stevens -- 17. Metals / Jill C. Merrill, Joseph J.P. Morton and Stephen D. Soileau -- 18. Ionizing Radiation / Lorris G. Cockerham, Thomas L. Walden, Jr., Cham E. Dallas, G. Andrew Mickley, Jr. and Michael A. Landauer -- 19. Plant and Animal Toxins / Frederick W. Oehme and Daniel E. Keyler -- 20. Use of Laboratory Animals in Toxicology Research / William J. White, C. Terrance Hawk and Mary Ann Vasbinder -- 21. Validation and Regulatory Acceptance of New, Revised, and Alternative Toxicological Methods / William S. Stokes and Leonard M. Schechtman -- 22. Acute Toxicity and Eye Irritancy / Mark E. Blazka and A. Wallace Hayes -- 23. Genetic Toxicology / David J. Brusick, Wanda R. Fields, Brian C. Myhr and David J. Doolittle -- 24. Short-Term, Subchronic, and Chronic Toxicology Studies / Nelson H. Wilson, Jerry F. Hardisty and Johnnie R. Hayes -- 25. Principles of Testing for Carcinogenic Activity / Gary M. Williams, Michael J. Iatropoulos and Harald G. Enzmann -- 26. Principles of Clinical Pathology for Toxicology Studies / Robert L. Hall and Nancy E. Events -- 27. Dermatotoxicology / Benjamin B. Hayes, Esther Patrick and Howard J. Maibach -- 28. Inhalation Toxicology / Rudolph Valentine and Gerald L. Kennedy -- 29. Detection and Evaluation of Chemically Induced Liver Injury / Gabriel L. Plaa and Michel Charbonneau -- 30. Principles and Methods for Renal Toxicology / Lawrence H. Lash -- 31. Gastrointestinal Toxicology / Robert W. Kapp, Jr. -- 32. Principles and Methods of Cardiac Toxicology / Y. James Kang -- 33. Assessment of Male Reproductive Toxicity / Sally D. Perreault, Gary R. Klinefelter and Eric Clegg -- 34. Test Methods for Assessing Female Reproductive and Developmental Toxicology / Mildred S. Christian -- 35. Hormone Assays and Endocrine Function / Robert W. Kapp, Jr. and John A. Thomas -- 36. Immunotoxicology: Effects of and Response to Drugs and Chemicals / Jack H. Dean, Robert V. House and Michael I. Luster -- 37. Assessment of Behavioral Toxicity / Deborah A. Cory-Slechta and Bernard Weiss -- 38. Application of Isolated Organ Perfusion Techniques in Toxicology / Harihara M. Mehendale -- 39. Organelles as Tools in Toxicology / Bruce A. Fowler, Mary L. Haasch, Katherine S. Squibb and A. Wallace Hayes -- 40. Analysis and Characterization of Enzymes and Nucleic Acids / F. Peter Guengerich and Cheryl J. Bartleson -- 41. Modern Instrumental Methods for Studying Mechanisms of Toxicology / Peter A. Crooks, David R. Worthen, Gary D. Byrd, J. Donald deBethizy and William S. Caldwell -- 42. Methods in Environmental Toxicology / Michael A. Lewis, Anne Fairbrother and Robert E. Menzer. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition provides comprehensive coverage in a manageable and accessible format. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. |
