| Contents Notes |
Preface -- Recent morphological studies of toxic neuropathy / P.S. Spencer and H.H. Schaumburg -- Axonal flow and toxic neuropathies / B. Droz and M. Chrétien -- Delayed neurotoxicity induced by organophosphorus compounds - areas of -- understanding and ignorance / M.K. Johnson -- Clinical and experimental work in neurotoxicity / A. Bischoff -- Safety evaluation of four bicyclic musk fragrance-chemicals relative to the neurotoxin, acetyl ethyl tetramethyl tetralin (AETT) / Y. Gressel, W.R. Troy, G.V. Foster -- Brain slices, assay systems for the neurotoxicity of environmental pollutants and drugs on mammalian central nervous system / Y. Kuroda -- Inhibitor characteristics of native, solubilized, and lipid-reconstituted neurotoxic esterase / C.S. Davis, M. L. Barth, B.R. Dudek and R.J. Richardson -- Neurotoxicity of lead in rabbits / E. Hietanen, J. Kilpio, U. Koivusaari, T. Nevalainen, M. Narhi, -- H. Savolainen and H. Vainio -- Neuropathological changes caused by trialkyllead compounds in the rat / A.A. Seawright, A.W. Brown, W.N. Aldridge, R.D. Verschoyle and B. W. Street -- Methyl mercury poisoning in mothers and their suckling infants / L. Amin-Zaki, S.B. Elhassani, M.A. Majeed, T.W. Clarkson, R.A. Doherty and M.R. Greenwood -- The effect of the gastrointestinal flora on tissue content of mercury and organ mercurial neurotoxicity in rats given methylmercuric chloride / I.R. Rowland, M.J. Davies and J.G. Evans -- Effects of xylene and alcohol on human visual evoked potentials / A.M. Seppäläinen, K. Savolainen and T. Kovala -- Sensitivity of rat brain synaptosomal ATPases to several structurally related organochlorine compounds / D. Desaiah, C.H. Trottman and S. K. Bansal 87 -- Effects of long term exposure to trichloroethylene on learning behavior in rats / T. Ikeda, R. Kishi and H. Miyake -- Neurologic response to white spirit exposure / K-H. Cohr, J. Stokholm and P. Bruhn Appraisal of the merits and short comings of tests of mutagenic potential / I. F. H. Purchase -- The induction of mutation and differentiation in mammalian cells by chemicals which initiate or promote tumor formation / E. Huberman -- Problems associated with the metabolic activation of carcinogens and mutagens in short-term tests / H. Bartsch -- Cell culture systems for studying multi factor interactions in carcinogenesis / I.B. Weinstein -- In vivo methods for evaluating genotoxicity / J. A. Swenberg -- Limitations of metabolic activation systems used in short-term tests for carcinogens / C.A. H. Bigger and A. Dipple -- Effect of glutathione and uridine 5'-diphosphoglucuronic acid on benzo(a)pyrene mutagenesis in the Salmonella/microsome assay / C. Malaveil le, G. Brun, A. Hautefeuille and H. Bartsch -- Metabolic inactivation of mutagenic benzo(a) pyrene metabolites: significance to carcinogenicity and implications for invitro tests / H.R. Glatt, K.L. Platt, K. Vogel, M. Bucker, R. Billings and F. Oesch -- Cell culture systems to study glial transformation / J.P. Bressler, R. Cole and J. de Vellis -- Studies on the mechanism of the synergistic carcinogenic response reported between ethylene dibromide and disulfiram and the implications for short term predictive screening tests / B.M. Elliott and J. Ashby -- Increased sensitivity of the SCE-test with rabbit lymphocytes by an exogeneous metabolic system / D. H. Waalkens, H. F. P. Joosten, T. D. Yih and A. Hoekstra Activation of chemicals to proximal carcinogens / T. Sugimura, K. Wakabayashi, M. Yamada, M. Nagao and T. Fujino -- Reaction with DNA and DNA-repair in chemical carcinogenesis / P. F. Swann and S.A. Kyrtopoulos -- Morphological correlates of irreversible tumor formation / G.C. Hard -- Alkylation of nucleic acid bases by epoxides and glycidyl ethers / K. Hemminki and H. Vainio -- Mechanism of inhibition of enzymatic DNA methylation by N-2-acetylaminofluorene bound to DNA / A. Pfohl-Leszkowicz, C. Salas, R.P.P. Fuchs and G. Dirheimer -- Formation of precancerous islands in rat liver and modification of DNA by ethyl carbamate: implications for its metabolism / E. Scherer, A.P. Steward and P. Emmelot -- On the metabolism of various polycyclic aromatic hydrocarbons (PAH) by liver microsomes of variously pretreated rats / A. Schmoldt, J. Jacob and G. Grimmer -- Synergistic effects of cigarette smoke extracts, benz(a)pyrene and nickel sulphate on morphological transformation of hamster embryo cells / E. Rivedal, J. Hemstad and T. Sanner -- Irreversible macromolecular binding of the flame retardant tris (2,3-dibromopropyl) phosphate in vitro and in vivo / E. Dybing, E.J. Soderlund and S.D. Nelson -- Carcinogenic potential of dichloroacetylene / D. Reichert, U. Spengler, W. Romen and D. Henschler -- Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats / G. Eisenbrand and M. Habs -- Comparative study on the metabolism and activation of aflatoxin B1 in nuclei, microsomes and reconstituted P-450 system of rat liver / Y. Ueno, H. Yoshizawa and R. Uchimaru -- Carcinogenicity of formaldehyde vapor: interim findings in a long-term bioassay of rats and mice / J. Swenberg, W. Kerns, K. Pavkov, R. Mitchell and E. J. Gralla -- Detection of mutagens in various alcoholic beverages, particularly in apple brandy, a product of western France / C. Loquet, G. Toussaint and J. Y. LeTalaer Epidemiologic approach to subclinical effects of metals in long-term occupational exposure / H. Sakurai -- Neurotoxic effects of long-term exposure to organic hydrocarbon solvents. Epidemiologic aspects / S. Hernberg -- Identification of human toxicity and carcinogenicity by ethylene derivatives / C.H. Tamburro and R.A. Greenberg -- Biological monitoring of exposure to chemical pollutants; exposure tests, biological limits and methods of analysis: a review / Z. Bardodej -- Cytogenetic and cytokinetic investigations on lymphocytes from workers -- occupationally exposed to tetrachloroethylene / M. Ikeda, A. Koizumi, T. Watanabe, A. Endo and K. Sato -- Health effects of long-term occupational exposure to polychlorinated biphenyls / M. Maroni, A. Colombi, C. Antonini and V. Foa' -- Behavior of indicators of dose and effect after cessation of occupational exposure to lead -- L. Alessio, M.R. Castoldi, P. Odone and I. Franchini -- Renal function impairment in lead-exposed workers: correlations with zinc protoporphyrin and blood lead levels / R. Lil is, A. Fischbein, J. Valciukas, W.E. Blumberg and I. J. Selikoff -- Evaluation of occupational exposure to metallic mercury and of its early renal effects / M. Berode, M. P. Guillemin, B. Martin, L. Balant, R. Fawer, P.O. Droz, P. Madelaine and M. Lob. Biological evaluation of hemoperfusion in acute poisoning / C. Bismuth and P.E. Fournier -- A toxicological evaluation of hemoperfusion using pharmacokinetic principles / G. de Groot, R.A.A. Maes and A.N.P. van Heijst -- Liaison with industry in the provision of essential information for the management of poisoning II / R. Goulding -- Results and perspectives of electroencephalography in toxicology / F. Mellerio -- Evaluation of haemoperfusion by column analysis / F.A. De Wolff, N.D. Smit, E.J. Grèunewald and L. M. Schicht -- Comparison of hemoperfusion and hemodialysis clearances during combined and prolonged treatment of severely poisoned patients / G.A. Verpooten, A. Heyndrickx, P. Zachee and M.E. De Broe -- Prognosis and treatment of methanol intoxication / R.L. Lins, P. Zachee, M. Christiaens, F. Van De Vijver, L. De Waele, P. Sandra and M.E. De Broe -- Sodium nitroprusside: comparison of the antidotal effect of hydroxocobalamin and sodium thiosulfate in rabbits / J. Pill, P. Engeser, M. Hobel and V.A.W. Kreye -- Regulatory issues in toxic substances control legislation / J. C. Davies -- Tier testing systems in toxicology and decision-making criteria for their use / B. D. Astill, H.B. Lockhart, J.B. Moses, A. Nasr, R.L. Raleigh and C.J. Terhaar -- Toxicity testing, hazard assessment and data quality assurance for chemical regulatory purposes / P.R.B. Noel -- The international program on chemical safety / E. Somers -- Toxicological aspects of European community legislation regarding new chemicals / M.-Th. Van Der Venne, A. Berl in, W.J. Hunter and P. Recht -- Liaison with industry in the provision of essential information for the management of poisoning / J.B. Spooner -- Toxicology advisory guidelines for fragrance safety assurance / G.R. Thompson, F.H. Stults, E.J. Moran, K.R. Tyburcy, D.M. Ford and L.G. Scharpf, Jr. UDP-glucuronosyltransferase activity of cultured eel ls in situ and in vitro / J. Singh and F.J. Wiebel -- In vitro comparative bioactivation of aliphatic halogenated hydrocarbons / I.G. Sipes and A.J. Gandolfi -- The hepatobiliary toxicity of penicillic acid, a carcinogenic mycotoxin / P.K. Chan and A.W. Hayes -- Hexachlorobenzene and 2, 4, 5, 2; 4; 5'-hexachlorobiphenyl - a comparison of their distribution, biotransformation and porphyrinogenic action in female rats / G. Koss, S. Seubert, A. Seubert, M. Herbert, W. Koransky and H. Ippen -- Effects of dietary vitamin A (retinal) on the reduction of hepatic retinal storage caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin / T. Thunberg and U.G. Ahlborg -- Changes in rat liver morphology and metabolic activities after exposure to chlorinated paraffins / O.G. Nilsen, R. Toftgard and H. Glaumann -- Whole body distribution of 3H levamisole in rats and mice / P. Benard, C. Brunet, M. Cazin, J.P. Braun, V. Burgat-Sacaze and A.G. Rico -- The metabolism of 2-bro¨mo-[1- 14c] ethan-1-amine (BEA): a model compound for inducing renal papillary necrosis (RPN) / P.H. Bach, R. Christian, J. Baker and J.W. Bridges -- Detection of chemical-induced porphyria in man. Possibilities in biomonitoring of exposure to chemicals / J.J T.W.A. Strik. Excretion of metals into the intestine; a comparative study in rats / S.G. Schafer and W. Forth -- Permeability of the lung to inhaled heavy metals / D.B. Menzel, S.J. Williams, J.A. Graham, F.J. Miller and D.H. Gardiner -- Subchronic effects induced by NiO-inhalation in Wistar rats / C.H. Weischer, H. Oldiges, D. Hochrainer and W. Kèordel -- Metabolic patterns of low and toxic doses of thallium in the rat / E. Sabbioni, E. ¨Marafante, J. Rade, A. Di Nucci, C. Gregotti and L. Manzo -- Excessive thallium absorption among a population living near a thallium emitting cement plant / A. Brockhaus, R. Dolgner, U. Ewers, H. Wiegand, I. Freier, E. Jermann -- and U. Krämer -- Metabolism of orally ingested cadmium in humans / Z.A. Shaikh and J.C. Smith 569 -- Sex-1 inked distribution of cadmium, zinc and copper in tissues of cadmium-treated rats / S. Gabor and Z. Anca -- Comparison of bone lesions in chronic cadmium poisoning and vitamin D deficiency -- K. Nogawa and E. Kobayashi -- The influence of arsenite on the interaction between selenite and methyl mercury -- J. Alexander -- Interference of inadequate oxygenation in hematofluorometer zincprotoporphyrin readings / -- S. Telišman, V. Karaciâc, J. Meczner and D. Prpiâc-Majiâc -- Neurogenic components in cardiovascular reactivity of chronically lead exposed rats -- M. Carmignani, P. Bosco lo, P. Marchetti and A. Iannaccone -- Effect of oral zinc intake on the biological effect of lead / M. Abdulla -- Biological monitoring of children living in the vicinity of a lead smelting plant / D. Prpiâc-Majiâc, B. Matijeviâc, V. Karaciâc and A. Keérsanc -- Statistical study of some parameters able of influencing blood lead levels / G. Ducoffre, P. Bruaux, F. Claeys-Thoreau, A. Lafontaine, E. Schifflers and M. Smans. Toxic interactions with dermal exposure to organophosphate insecticides / S. D. Murphy -- Biochemical changes in the rat cerebellum following cypermethrin administration / E. A. Lock and P.N. Berry -- Hexac hlorobenzene (HCB) and some of its sulfur-containing metabolites: tissue retention and excretion routes in mice / I. Brandt, A. Lydén, P. Slanina and L. Albanus -- Tox icology of trimethyl- and triethyl phosphorothioates / R. D. Verschoyle, W.N. Aldridge and J.R.P. Cabral -- In vivo studies on adriamycin-induced lipid peroxidation and effects of ferrous ions / H. Kappus, H. Muliawan and M.E. Scheulen -- The use of biochemical methods for detecting changes in eel l population of rat bone marrow / A. F. Wright and M.S. Rose -- Rate of skin penetration of organophosphates measured in diffusion eel ls / C. van Hooidonk, B. I. Ceulen, H. Kienhuis and J. Bock -- The effect of hydralazine on collagen biosynthesis and secretion in isolated embryonic chick tendon cells / R.I. Bashey, S.A. Jimenez and T. Balazs -- A sensitive experimental model for the assessment of hepatotoxicity by halogenocompounds: prolactin binding to the specific receptors / R. Di Carlo, G. Muccioli, D. Lando, 0. Brossa, E. Burdino, I. Chiappino, O. Danni, S. Mina and G. Ugazio. A collection of papers dealing collected in the hope that it will serve a useful purpose to experienced scientists, government officials and all interested in mechanisms of action and hazard evaluation of chemicals. |
