Record Display for the EPA National Library CatalogRECORD NUMBER: 4 OF 13
|Main Title||Initial Submission: Preliminary Study of the Effect of Toluene on Pregnancy of the Rat (Inhalation Exposure). Final Report with Cover Letter dated 07/22/92.|
|CORP Author||Huntingdon Research Centre PLC (England). ;American Petroleum Inst., Washington, DC.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||24 Jun 1992|
|Additional Subjects||Toluene ; Toxicity testing ; Pregnancy ; Rats ; Inhalation tests ; In utero ; Narcosis ; Solvents ; Fetuses ; Dosage ; Maternal toxicity ; American Petroduleum Institute|
In this assessment of the effect of Toluene, a solvent, on the pregnancy and in utero development of the rat, dosages of 0, 500, 1000, 2000, 3500 and 5000 ppm were administered by inhalation for a period of 6 hours a day from Day 6 to 15 of pregnancy inclusive. On Day 20, surviving females were sacrificed, subjected to post mortem examination with liver weights being recorded. Litter values were determined and fetuses were examined externally.