||Health assessment document for toluene /
Basu, Dipak ;
Bosch, Stephen ;
Colman, Joan ;
Durkin, Patrick ;
||Syracuse Research Corp., NY. Center for Chemical Hazard Assessment.;Environmental Protection Agency, Research Triangle Park, NC. Environmental Criteria and Assessment Office.
|| U.S. Environmental Protection Agency, Office of Research and Development, Environmental Criteria and Assessment Office,
||EPA-600/8-82-008; EPA-68-02-3277; 600D82380
Toluene--adverse effects. ;
Industrial medicine ;
Aromatic hydrocarbons ;
Central nervous system ;
Air pollution ;
Physical properties ;
Chemical properties ;
Air pollution effects(Humans) ;
Threshold limit values ;
Toxic substances ;
Occupational safety and health ;
Analytical methods ;
||OCSPP Chemical Library/Washington,DC
||Region 10 Library/Seattle,WA
||Some EPA libraries have a fiche copy filed under the call number shown.
||2 pts. (various pagings) : ill.
The health effect of primary concern with regard to exposures of humans to toluene is dysfunction of the central nervous system (CNS). Occupational exposures in the range of 200 to 1,500 ppm have elicited dose-related CNS alterations. Although myelotoxicity was previously attributed to toluene, recent evidence indicated that toluene is not toxic to the blood or bone marrow; myelotoxic effects are considered to have been the result of concurrent exposure to benzene. Available evidence is inadequate for assessing the carcinogenic potential of toluene. Although a 24-month inhalation exposure of rats to 300 ppm did not produce any positive carcinogenic effects, various design deficiencies precluded the usefulness of this study in assessing carcinogenic potential.
"Review Draft." "EPA-600/8-82-008" (cover). "March 1982" (cover). Includes bibliography.