||Initial Submission: TSCA Health and Safety Study Cover Sheet with Continuation Sheet Summarizing Pilot Study on Developmental Toxicity in Rats after Oral Administration of ALM 2647, dated 10/05/99.
||Bayer A.G., Wuppertal (Germany, F.R.).;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||12 Oct 1999
Laboratory animals ;
Oral ingestion ;
Body weight ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Eight mated female Wistar rats each were daily treated orally by gavage with ALM 2647 in 0.5% aqueous carboxymethylcellulose from day 6 to day 19 p.c. with doses of 0, 10, 30 and 100 mg/kg body weight (bw)/day (dose-volume 10 ml/kg bw). The fetuses were delivered by cesarean section on day 20 p.c. Investigations were performed on general tolerance of the test compound by the females as well as on its effect on intrauterine development. 2/3 of fetuses underwent skeletal evaluation while 1/3 of fetuses were evaluated viscerally.