Record Display for the EPA National Library Catalog
RECORD NUMBER: 41 OF 96
|OLS Field Name||OLS Field Data|
|Main Title||Initial Submission: TSCA Health and Safety Study Cover Sheet Reporting Preliminary Results from Developmental Toxicity Screening in Rats after Oral Administration of and 7370, dated 08/16/1999.|
|CORP Author||Bayer A.G., Dormagen (Germany, F.R.).; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Additional Subjects||Toxicology ; Oral administration ; Rats ; Toxicity ; Dosage ; Females ; Pregnancy ; Gavage ; Fetuses ; Tolerance ; Weight ; Mortality ; Evaluation ; Laboratory animals ; Toxic substances ; AND 7370 ; Experimental herbicide ; CAS No 99-2-58|
Four inseminated Wistar rats (two rats in the 100 mg/kg dose group had implantation sites; i.e., were pregnant) were treated daily from day 6 to day 19 p.c. by gavage, with 100 or 1000 mg/kg body weight/day of AND 7370 in 0.5% carboxymethylcellulose in demineralized water. The fetuses were delivered by cesarean section on day 20 p.c. Investigations were performed on the general tolerance of the test compound by the females as well as on its effects on intrauterine development (pregnancy rate, number of fetuses and resorptions, external findings in the fetuses, fetal weight, fetal skeletal malformations, and fetal skeletal variations (wavy ribs only)).