| Main Title |
Evaluation of DNA Damage in the Oral Mucosa of Tobacco Users and Non-Users by (32)P-Adduct Assay. |
| Author |
Chacko, M. ;
Gupta, R. C. ;
|
| CORP Author |
Baylor Univ., Houston, TX. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1988 |
| Year Published |
1988 |
| Report Number |
EPA/600/J-88/468; |
| Stock Number |
PB90-147737 |
| Additional Subjects |
Tobacco ;
Carcinogens ;
Evaluation ;
Comparison ;
Smoking ;
Reprints ;
DNA adducts ;
Mouth mucosa ;
Tobacco use disorder ;
Smokeless tobacco
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB90-147737 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Tobacco and its combustion products contain several known or potential human carcinogens and studies are not beginning to emerge for detecting DNA and protein adducts in tobacco users. A highly sensitive (32)P-adduct assay, capable of measuring a wide spectra of aromatic and/or hydrophobic DNA adducts, was used to evaluate tobacco use-related adducts in human oral mucosal cells. The chromatographic behavior of the oral mucosal DNA adducts by selective PE1-cellulose TLC and their extractability in 1-butanol suggest that they have an aromatic and/or hydrophobic moiety and two of the major adducts have been tentatively assigned as aromatic amine derivatives. |
