Record Display for the EPA National Library Catalog

RECORD NUMBER: 35 OF 87

Main Title Initial Submission: Four-Week Range Finding Inhalation Studies in Rats with Titanium Dioxide with Cover Letter dated 08/10/1992.
CORP Author Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 8EHQ-1092-11723
Stock Number OTS0571651
Additional Subjects Toxicology ; Health effects ; Titanium dioxide ; Subchronic toxicity ; Mammals ; Rats ; Inhalation ; CAS No 13463-67-7
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NTIS  OTS0571651 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 440p
Abstract
Four groups of 25 male rats were exposed in a similar manner to air and served as controls. Ten rats from each group were subjected to a clinical laboratory evaluation following the twentieth exposure. Five of these rats from each group received a second clinical laboratory evaluation after a fourteen-day recovery period. For each formulation tested, five rats per group (including control groups) were sacrificed for histopathological examination on the last day of exposure and at fourteen days and three, six, and twelve months post-exposure.