||Initial Submission: Four-Week Range Finding Inhalation Studies in Rats with Titanium Dioxide with Cover Letter dated 08/10/1992.
||Du Pont de Nemours (E.I.) and Co., Newark, DE. Haskell Lab. for Toxicology and Industrial Medicine.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Titanium dioxide ;
Subchronic toxicity ;
CAS No 13463-67-7
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Four groups of 25 male rats were exposed in a similar manner to air and served as controls. Ten rats from each group were subjected to a clinical laboratory evaluation following the twentieth exposure. Five of these rats from each group received a second clinical laboratory evaluation after a fourteen-day recovery period. For each formulation tested, five rats per group (including control groups) were sacrificed for histopathological examination on the last day of exposure and at fourteen days and three, six, and twelve months post-exposure.