Record Display for the EPA National Library CatalogRECORD NUMBER: 1 OF 9
|Main Title||Adenofibrosis in the Rat Liver, With Persistence of Polychlorinated Biphenyls in Adipose Tissue.|
|Author||Kimbrough, Renate D. ; Linder, Ralph E. ; Burse, Virlyn W. ; Jenning., Ralph W. ;|
|CORP Author||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.|
|Stock Number||PB-280 603|
|Additional Subjects||Pesticides ; Toxicology ; Rats ; Laboratory animals ; Ingestion(Biology) ; Exposure ; Experimental data ; Physiological effect ; Liver ; Tissue(Biology) ; Diet ; Chlorine organic compounds ; Dosage ; Pathology ; Reprints ; Adipose tissue ; Pesticide residues ; Bioaccumulation ; Adenofibrosis ; Aroclor 1254 ; Biphenyl/chloro ; Toxic substances ; Polychlorinated biphenyls|
Fifty male Sherman strain rats were fed 500 ppm of a polychlorinated biphenyl (PCB) (Aroclor 1254) for six months. Five each were killed zero, one, two, three, four, six, eight, and ten months after exposure to Aroclor had ceased. The livers of these rats were examined by light and electron microscopy. Liver lesions persisted although exposure to PCBs ceased. Ten months after exposure ceased, 1,192 ppm PCBs were still present in the rats' adipose tissue and 22.65 ppm in the rat livers. Aroclor patterns found in the tissues by electron capture gas chromatograhy differed from patterns of dietary Aroclors. Mass spectral analysis of liver and adipose tissue revealed three major Aroclor components with masses of 324, 358, and 392. These contained isotopic clusters indicative of the presence of Cl5, Cl6, and Cl7, respectively.