| Main Title |
Trimethyltin-Induced Changes in Gross Morphology of the Hippocampus. |
| Author |
Dyer, Robert S. ;
Deshields, Teresa L. ;
Wonderlin, William F. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA-600/J-82-119; |
| Stock Number |
PB83-191494 |
| Additional Subjects |
Hippocampus ;
Toxicology ;
Morphology ;
Rats ;
Laboratory animals ;
Degeneration ;
Reprints ;
Tin/trimethyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB83-191494 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
Acute exposure to trimethyltin (TMT) produces alterations in hippocampal morphology. The purpose of this study was to arrive at a simple method for quantitative assessment of the gross changes in morphology which could then be used as a correlate in studies of TMT toxicity. Adult Long-Evans male hooded rats were treated with a single dose of TMT chloride and sacrificed either (a) within 11 days; (b) following 30 days; or (c) 105 days following treatment. Among a variety of morphological measures explored, the easiest and most clearly dosage-related was length of the line of pyramidal cells, from CA1 through CA3c. TMT shortened this line in a dosage and time since treatment increased. It was concluded that this measurement may provide a useful morphological correlate for physiological and behavioral studies of TMT toxicity. |
