Record Display for the EPA National Library Catalog


Main Title Thyroid follicular cell carcinogenesis : mechanistic and science policy considerations.
Author Hill, R. N. ; Erdreich, L. S. ; Paynter, O. E. ; Roberts, P. A. ; Rosenthal, S. L. ;
CORP Author Environmental Protection Agency, Washington, DC. Office of Research and Development.
Publisher U.S. Environmental Protection Agency, Research and Development [Science Advisory Board],
Year Published 1987
Report Number EPA/625/3-88/014a
Stock Number PB88-230750
OCLC Number 699523910
Subjects Thyroid gland--Tumors--Research ; Thyroid gland--Cancer--Research ; Thyroid gland--Cancer--Prevention--Research
Additional Subjects United States--Environmental Protection Agency--Risk Assessment Forum ; Thyroid gland ; Endocrine gland ; Thyroid neoplasms ; Exposure ; Carcinogen risk assessment ; Carcinogenesis ; Thyroid follicular cells
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
ELBD ARCHIVE EPA 625-3-88-014a Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
NTIS  PB88-230750 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation x, 116, [41] p. : ill. ; 28 cm.
EPA's Guidelines for Carcinogen Risk Assessment call for use of mechanistic and other relevant information in making choices about the models to be used in extrapolating hazard estimates from high to low exposures. The Forum report on thyroid neoplasia proposes that, under clearly specified conditions, chemical carcinogenesis in thyroid follicular cells can be analyzed as a threshold phenomenon, rather than assuming low-dose linearity as EPA customarily does for carcinogenic compounds. Specifically, for chemicals that induce tumors only in the thyroid gland and alter pituitary-thyroid status, EPA scientists would use metabolic, toxicological, and ancillary data on preneoplastic end points to identify a NOAEL or LOAEL as the basis for a cancer potency estimate. The Forum report reviews the physiology and biochemistry of normal thyroid-pituitary function, discusses factors influencing thyroid carcinogenesis, and analyzes human data on thyroid hyperplasia and neoplasia.
"December 15, 1987; edited May 1988." "Prepared for the Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC, December 1987"--Beneath title. SAB review draft. "EPA/625/3-88/014A"--Cover. Includes bibliographical references (p. [20-41]) at end. "Do not quote or cite."