Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Risk assessment on (2,4,5-trichlorophenoxy) acetic acid (2,4,5-T), (2,4,5-trichlorophenoxy) propionic acid, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) /
CORP Author United States. Carcinogen Assessment Group.
Publisher U.S. Environmental Protection Agency, Carcinogen Assessment Group ; Available from the National Technical Information Service,
Year Published 1981
Report Number EPA 600-6-81-003
Stock Number PB 81-234825
OCLC Number 09337201
Subjects Tetrachlorodibenzodioxin--Toxicology.
Additional Subjects Toxicology ; Pesticides ; Carcinogens ; Dosage ; Chlorine organic compounds ; Laboratory animals ; Mice ; Rats ; Malignant neoplasms ; Epidemiology ; Dioxin/tetrachloro-dibenzo ; Carcinogenesis ; Toxic substances ; Silvex ; T 2-4-5 herbicide ; Cancer
Internet Access
Description Access URL
Local Library Info
Library Local Subject Local Note
EJB CAS no. 1746-01-6
Library Call Number Additional Info Location Last
EJBD ARCHIVE EPA 600-6-81-003 Headquarters Library/Washington,DC 03/17/2009
EJBD  EPA 600-6-81-003 c.1-2 Headquarters Library/Washington,DC 08/29/2011
ESAD  EPA 600-6-81-003 Region 10 Library/Seattle,WA 03/23/2010
NTIS  PB81-234825 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 01/01/1988
Collation 1 volume (various pagings) : illustrations ; 28 cm
Carcinogenic responses have been induced in mice and rats at low doses of TCDD. TCDD has been shown to be a cancer promoter. These results, together with the strongly suggestive evidence in epidemiology studies, constitute substantial evidence that TCDD is likely to be a human carcinogen. It appears that TCDD is a more potent carcinogen than aflatoxin B1 which is one of the most potent carcinogens known. The levels of TCDD (contained as an unavoidable contaminant of the 2,4,5-T) used in the 2,4,5-T studies apparently were too small to produce an observable response in those experiments. The lack of a statistically significant tumor incidence in most of the studies on the 2,4,5-T product may be attributed to the very low levels of TCDD in the product relative to the levels at which it produced carcinogenic effects in rats and mice, as well as to deficiencies of those studies. However, since TCDD is a carcinogen, any product containing TCDD, including 2,4,5-T and silvix, can be considered to pose a human carcinogenic hazard. Furthermore, a rat study on specially purified 2,4,5-T provides highly suggestive evidence that essentially pure 2,4,5-T may be a human carcinogen. Quantitative assessments have been calculated for the carcinogenic risk posed to humans.
Prepared for [the] Office of the General Counsel, U.S. Environmental Protection Agency. Prepared by [the] Office of Health and Environmental Assessment, Washington, D.C., Carcinogen Assessment Group. "PB 81-234825." Includes bibliographical references.