Record Display for the EPA National Library Catalog
RECORD NUMBER: 43 OF 221| Main Title | Initial Submission: a Range-finding Teratology Study in Albino Rabbits with Cga-71818 Technical (Final Report) with Attachments and Cover Letter Dated 01/07/1992. | |||||||||||
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| CORP Author | Wil Res Labs; CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1992 | |||||||||||
| Report Number | 88-920000626 | |||||||||||
| Stock Number | OTS0535183 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; 1-(2-(2 ; 4-dichloro phenyl)-n-pentyl) -1h-1 ; 2 ; 4-triazole ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rabbits ; Oral ; Gavage ; Toxic substances ; Laboratory animals ; CAS No 66246-88-6 | |||||||||||
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| Collation | 100p | |||||||||||
| Abstract | Penconazole (66246-88-6) was evaluated for developmental toxicity. Five pregnant New Zealand White rabbits per group were dosed with 0, 50, 100, 250, 500, or 1000 mg/kg/day by oral gavage on days 7-20 of gestation. All does at 500 and 1000 mg/kg/day died or were sacrificed moribund. Reduced body weight and food consumption were observed at 250 mg/kg/day. Increased resorptions, decreased number of live fetuses and decreased fetal weights were observed at 250 mg/kg/day. No external fetal malformations were observed. |