Record Display for the EPA National Library Catalog


Main Title Fornix Transections Disrupt the Ontogeny of Latent Inhibition in the Rat.
Author Nicolle, M. M. ; Barry, C. C. ; Veronesi, B. ; Stanton, M. E. ;
CORP Author Environmental Protection Agency, Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;NSI Technology Services Corp., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/338;
Stock Number PB90-201682
Additional Subjects Animal behavior ; Hippocampus ; Acetylcholinesterase ; Graphs(Charts) ; Reprints ; Ontogeny ; Taste aversion ; Latent inhibition ; Immunohistochemistry ; Weaning
Library Call Number Additional Info Location Last
NTIS  PB90-201682 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 11p
In three experiments, the study examined the ontogeny of latent inhibition in a conditioned taste aversion paradigm. In the first experiment, 18-, 25-, and 32-day-old rats received a pairing of a 0.6% Sanka solution with a LiCl injection (.75% BW, .4M) or physiologically balanced saline injection after either 4 preexposures to the taste or control treatment without taste preexposure. Experiment 2 investigated the possibility that a failure to observe latent inhibition in 18-day-old resulted from the particular experimental parameters employed in Experiment 1. In Experiment 2, taste exposure durations were longer, the retention interval between conditioning and testing was shorter, and deprivation conditions were more typical of those used with preweanling subjects. In Experiment 3, the study examined the effect of sham or fornix lesions at 18 days of age on latent inhibition at 32 days of age. Lesioned subjects exhibited equivalent conditioned taste aversions but failed to show latent inhibition.