The Susquehanna River Basin Commission (SRBC) conducts a water quality and biological assessment of each of the six major subbasins (Figure 1) about every 10 years on a rotating schedule. The SRBC assessment has provided information used to: evaluate the chemical, biological, and habitat conditions of streams in the basin; identify major sources of pollution and lengths of stream impacted; maintain a database that can be used to document changes in stream quality over time; review projects affecting water quality in the basin; and identify areas for more intensive study. SRBC surveyed the Upper Susquehanna Subbasin in 1998, and will coordinate with the Upper Susquehanna Coalition and other local interests to target followup sampling in priority watersheds in 1999. This follow-up sampling will be used to support local watershed protection and remediation activities.