Record Display for the EPA National Library Catalog


Main Title Metal-Induced Inhibition of Glutathione S-Transferases.
Author Massaro, E. J. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1985
Report Number EPA/600/D-85/091;
Stock Number PB85-218832
Additional Subjects Enzyme inhibitors ; Metals ; Environmental surveys ; Toxicity ; Complex compounds ; Bioassay ; Substrates ; Ions ; Antioxidants ; Detoxication ; Heavy metals ; Enzyme activity ; Alkenetransferases/glutathione ; Aryltransferases/glutathione ; Enzyme supports ; Biotransformation
Library Call Number Additional Info Location Last
NTIS  PB85-218832 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 20p
The glutathione S-transferases comprise a group of multi-functional enzymes involved in the biotransformation/detoxication of a broad spectrum of hydrophobic compounds bearing an electrophilic center. The enzymes facilitate the nucleophilic attack of the -SH group of reduced glutathione (GSH) on the electrophilic centers of appropriate substrates which is the first step in the physiological formation of mercapturic acids. In mammals, GSH-Tr activity has been demonstrated in the cytosolic and, in some cases, microsomal fractions of the cells of various organs. In the liver, these enzymes constitute from 3-10% of the cytosolic proteins. With the possible exception of the erythrocyte, GSH-Tr exists in cells in multiple molecular forms. It has been reported that the isozymes GSH-Tr can be distinguished from one another by their substrate specificities.