| Main Title |
Fetal Toxicity of Toxaphene in Rats and Mice. |
| Author |
Chernoff, N. ;
Carver., B. D. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, N.C. |
| Year Published |
1976 |
| Report Number |
EPA/600/J-76/059; |
| Stock Number |
PB-267 873 |
| Additional Subjects |
Toxicity ;
Insecticides ;
Pesticides ;
Toxicology ;
Congenital abnormalities ;
Pregnancy ;
Body weight ;
Brain ;
Pathology ;
Mortality ;
Dosage ;
Dose rate ;
Lethal dosage ;
Sublethal dosage ;
Rats ;
Mice ;
Laboratory animals ;
Bioassay ;
Terpenes ;
Chlorine aliphatic compounds ;
Toxaphene ;
Fetuses ;
Encephalocele ;
Reprints
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB-267 873 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
7p |
| Abstract |
Toxaphene administration at dose levels sufficient to cause a high degree of maternal toxicity in the rat resulted in a reduction in fetal weight and a decrease in the degree of skeletal ossification. In the mouse the only significant fetal effect noted was an incidence of encephaloceles. This defect was found only at the highest dose level, one which also resulted in overt maternal toxicity as evidenced by an increased incidence of maternal death and a reduction in weight gain. It thus appears that the administration of toxaphene to rats and mice during the period of embryonic organogenesis results in some fetotoxic effects at levels which cause maternal toxicity. |
