The US EPA Office of Research and Development is supporting a Small Quantity Generator Research Program to develop and promote the use of innovative technologies and management practices to reduce the generation of hazardous waste. The program was established in response to the needs of small quantity generators in the areas of waste management, regulatory compliance, and technical resources. Waste reduction is seen as a key in helping small businesses by reducing liability, product costs, disposal costs, and environmental, safety and health concerns. To date, a total of three efforts are on-going under the program with the State of North Carolina, the State of Minnesota, and the Governmental Refuse Collection and Disposal Association (CRDCA). Results from each of the three research efforts will be used to assist small businesses work toward waste reduction, improve waste management, and achieve regulatory compliance.