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Main Title Acute Exposure to Tris(2-Chloroethyl)Phosphate Produces Hippocampal Neuronal Loss and Impairs Learning in Rats.
Author Tilson, H. A. ; Veronesi, B. ; McLamb, R. L. ; Matthews, H. B. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC.
Publisher c1990
Year Published 1990
Report Number EPA/600/J-90/417;
Stock Number PB91-171728
Additional Subjects Toxicology ; Hippocampus ; Nerve cells ; Learning ; Seizures ; Health hazards ; Spatial discrimination ; Memory ; Atropine ; Rats ; Dose-response relationships ; Histology ; Reprints ; Tris(2-chloroethyl)phsphate ; Chlordiazepoxide
Library Call Number Additional Info Location Last
NTIS  PB91-171728 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 18p
Adult female, Fischer-344 rats were exposed to 275 mg/kg of tris(2-chloroethyl)phosphate (TRCP) by gavage. TRCP produced consistent signs of convulsive activity within 60-90 minutes after dosing and extensive loss of CA1 hippocampal pyramidal cells when examined 7 days after dosing. At the light microscopic level, toxic effects of TRCP on pyramidal cells in the CA3, and CA4 and granule cells in the dentate gyrus were less severe than on the CA1 cells. The seizure-related and neurohistological effects of TRCP were significantly attenuated by pretreatment with atropine or chlordizepoxide, suggesting that the hippocampal damage was related to the seizures produced by TRCP. In a second experiment designed to assess the potential health risk associated with TRCP, exposed rats were mildly impaired in the acquisition of a reference memory task in a water maze. However, TRCP-exposed rats were consistently impaired in performing a repeated acquisition task in the water maze. These data underscore the potential health risk associated with exposure to TRCP and support the conclusion that the hippocampus is intimately involved in spatial memory in rats. (Copyright (c) 1990 Academic Press Inc.)