Record Display for the EPA National Library Catalog


Main Title Electrophysiological Systems for Neurotoxicity Field Testing: PEARL II and Alternatives.
Author Otto, D. A. ; Hudnell, H. K. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.
Publisher 10 Feb 89
Year Published 1989
Report Number EPA/600/D-89/092;
Stock Number PB89-223986
Additional Subjects Toxicity ; Electrophysiologic recording ; Evoked potentials ; Exposure ; Computer systems hardware ; Computer systems programs ; Proving ; Lead poisoning ; PEARL II ; Neurotoxins ; Auditory cortex ; Visual cortex ; Somatosensory cortex
Library Call Number Additional Info Location Last
NTIS  PB89-223986 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 22p
PEARL II, a computerized battery of electrophysiological tests designed for neurotoxicity field testing, was developed a decade ago. The battery includes sensory evoked potentials (auditory, somatosensory and visual), event-related slow brain potentials (CNV, P300), and associated behavioral measures. Field-testing capabilities have been demonstrated in pediatric lead studies. Several dozen PEARL II systems are currently being used in fixed-base laboratories. Factors which limit the use of PEARL II in neurotoxicity field testing include: operation and maintenance of the system requires a highly trained staff; PEARL II is a relatively expensive system; it is not commercially available or serviced; the hardware is obsolescent. Although sensory evoked potential tests have proven to be very sensitive to chemical exposure in humans and animals, the effectiveness of such tests for neurotoxicity screening of exposed populations has not been demonstrated. Several commercial systems suitable for neurotoxicity field testing are reviewed briefly. Electrophysiological tests of visual toxicity currently under development are also described.