The software is designed for analyzing mutagenicity data from the Salmonella Assay (Ames test). The program will automatically supply an accepted method of statistical analysis and will, optionally, supply statistics from several different models, thereby eliminating a potentially major source of variability between investigators. Statistics supplied include: (1) the initial slope of the dose-response curve (potency estimate); (2) a determination as to whether the computed slope is statistically different than zero (model dependent mutagenicity determination); and (3) an indication of whether each dose is significantly different than the background (t-Test). A glossary of terms and abbreviations used in the manual is provided in Appendix A. Software Description: The software is written in the Turbo C programming language for implementation on IBM-PC/XT/AT and compatible machines using MS-DOS, PC-DOS operating system. Minimum memory requirement is 512K.