||Health Effects Research Lab., Research Triangle Park, NC. ;Western Illinois Univ., Macomb. Dept. of Biological Sciences. ;Universidad Autonoma de Queretaro (Mexico). ;Charles River Analytics, Inc., Cambridge, MA. ;Ontario Ministry of the Environment, Rexdale. Biohazard Lab.
Four coded chemicals, azidoglycerol (AG), methyl nitrosourea (MNU), sodium azide (NaN3), and maleic hydrazide (MH) were tested with the Tradescantia micronucleus (Trad-MCN) bioassay by five independent laboratories from five different countries. The purpose of this international collaborative study was to evaluate four plant bioassays, of which the Trad-MCN assay was one, their sensitivity, efficiency, and reliability. The study was carried out under the auspices of the International Program on Chemical Safety, the World Health Organization, and the United Nations Environmental Program. The conclusions from this study suggest that under normal conditions, the Trad-MCN bioassay is an efficient and reliable short-term bioassay for clastogens. It is suitable for the rapid screening of chemicals, and also is specially qualified for in situ monitoring of ambient pollutants. (Copyright (c) 1994 Elsevier Science B.V.)