||Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity.
Chadwick, R. W. ;
Chang, J. ;
Forehand, L. R. ;
Long, J. E. ;
Duffy, M. C. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Small intestine ;
Intestinal mucosa ;
Gas chromatography ;
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The effect of daily p.o. injections of 20 mg/kg lindane on nitroreductase, azoreductase, B-glucuronidase, dechlorinase and dehydrochlorinase enzyme activity in the rat intestinal tract was investigated after 2 weeks and 5 weeks of treatment. Antibiotics were administered to half of the treated rats after 4 weeks of treatment. Results of the study indicated that lindane significantly increased nitro reductase and azoreductase activity in the small intestine, that there were regional differences in the effect of lindane as well as differences dependent on the exposure duration. The results also suggest the presence of substantial levels of mucosal enzyme in the small intestine.