Record Display for the EPA National Library Catalog


Main Title Dermal Carcinogenesis Assay in C3H/HEJ Mice with Cover Letter dated 07/18/86.
CORP Author Exxon Corp., East Millstone, NJ. Research and Environmental Health Div.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 24 Jul 1986
Year Published 1986
Report Number 8EHQ-0886-0306/0316;
Stock Number OTS-0200627-1
Additional Subjects Skin(Anatomy) ; Carcinogenesis ; Mice ; Toxicology ; Oncogenes ; Skin neoplasms ; Assaying ; Body weight ; Laboratory animals ; Dermal growth ; Chemical analysis ; Death ; Clinical observation ; Dose-response relationships ; Evaluation ;
Library Call Number Additional Info Location Last
NTIS  OTS-0200627-1 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 1081p
The objective of this study was to evaluate the oncogenic potential of test materials MRD-82-18, MRD-82-57A, MRD-82-142, and MRD-82-153 through MRD-82-157, MRD-82-19A, MRD-82-19A, and MRD-82-19C when applied to mouse skin. The study was initiated with 510 male C3H/HeJ mice which were divided into 9 groups of 50 mice each and 3 groups of 20 mice each. The animals of Groups 1 through 11, and 14 through 16 received 25 micro liters of undiluted test material to the clipped backs 3 times per week until death of the animals; Group 13 served as a shaved control which did not received any test material but was assigned test material number MRD-82-158, and Group 12 served as the negative control receiving 25 microliters of MRD-82-157. (All statistical analyses were run against Group 12, the control group).