Record Display for the EPA National Library CatalogRECORD NUMBER: 19 OF 37
|Main Title||Interim Report of Mouse Skin-Painting Test Results with Aromatic Petroleum Pitch with Cover Letter dated 07/14/80.|
|CORP Author||Standard Oil Co. (Ohio), Cleveland.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.|
|Publisher||21 Jul 1980|
|Additional Subjects||Skin diseases ; Mice ; Toxicity ; Solvents ; Dosage ; Carcinoma ; Tumors ; Aromatics ; Body fluids ; Toluene ; Laboratory tests ; Exposure ; Bioavailability ; Laboratory animals ; Aromatic petroleum pitch ; Standard Oil Company|
This report summarizes significant data obtained after 59 weeks of a projected lifetime mouse skin-painting study instituted to assay the carcinogenic potential of products produced from the oxidative condensation of an intermediate clarified oil solvent extract (CAS Registry No. 64741-62-4). The results obtained support the conclusion that at high dose levels when all or a portion of the test materials are made bioavailable via salvation in toluene, skin tumors are induced. The bioavailability of the solid test materials via solvation in normal body fluids (e.g. sweat, saliva, gastro-intestinal fluids, etc.) was not addressed in this study.