Record Display for the EPA National Library Catalog
RECORD NUMBER: 1843 OF 2056| Main Title | Theoretical foundations of cancer chemotherapy introduced by computer models | |||||||||||
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| Author | Jackson, Robert C. | |||||||||||
| Publisher | Academic Press, | |||||||||||
| Year Published | 1992 | |||||||||||
| OCLC Number | 25592026 | |||||||||||
| ISBN | 0123790301 | |||||||||||
| Subjects | Cancer--Chemotherapy--Computer simulation ; Pharmacokinetics--Computer simulation ; Cancer cells--Computer simulation ; Antineoplastic Agents--pharmacokinetics ; Computer Simulation ; Models, Chemical ; Neoplasms--drug therapy | |||||||||||
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| Collation | xiv, 447 p. : ill. ; 24 cm. + 1 computer disk (5 1/4 in.) | |||||||||||
| Notes | System requirements for computer disk: IBM PC or compatible; IBM-BASIC, BASICA, or Microsoft GWBASIC (need Microsoft Quick Basic 4.5 to compile source codes). Includes bibliographical references (p. 427-435) and index. |
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| Contents Notes | Introduction: models as tools for teaching and research -- Cell cycle effects of drugs -- Anticancer drug selectivity -- Quiescent cells, differentiated cells, and lost cells -- Pharmacokinetic models -- Invasion and metastasis -- Blood-brain barrier -- Cancer treatment and the immune response -- Drug resistance and its implications for treatment strategy -- Growth kinetics of large tumors -- Biochemical basis of anticancer drug selectivity -- Biochemical principles of drug interaction -- Cytokinetics, pharmacokinetics, and inhibition kinetics: a unified model. |