||Letter from Union Carbide Corporation to the USEPA Submitting Information on the 28-Day Inhalation Study with Trimethyl Silane Vapor in Rats.
||Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
||29 Mar 1988
Body weight ;
Laboratory animals ;
Food intake ;
Wounds and injuries ;
Union Carbide Corp
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
Dow Corning Corporation submitted the results of a 28-day inhalation study of trimethoxysilane (CAS No. 2487-90-3) vapor. This study showed that repeated exposure to rats to trimethoxysilane vapor concentrations of 5 and 10 ppm produced a high incidence of mortality and lung injury in the form of ateleclasis and inflammatory change. Rats exposed to 0.5 ppm had only reduced food intake and reduced body weight gain. Union Carbide Corporation has recently undertaken studies on the acute inhalation toxicity of trimethoxysilane vapor, and this information is herewith submitted as a supplemental report to Dow Corning's 1980 submission.