Record Display for the EPA National Library Catalog


Main Title Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets /
Author Boelsterli, Urs A.,
Publisher CRC Press,
Year Published 2007
OCLC Number 74459862
ISBN 9780849372728; 0849372720
Subjects Molecular toxicology. ; Toxicology--methods. ; Molecular Biology--methods. ; Signal Transduction. ; Xenobiotics--pharmacokinetics. ; Xenobiotics--toxicity. ; Toxicologia. ; Transduðcäao de sinal celular. ; Biologia molecular.
Internet Access
Description Access URL
Table of contents
Publisher description
Library Call Number Additional Info Location Last
EKBM  RA1220.3.B64 2007 Research Triangle Park Library/RTP, NC 08/08/2011
ELBM  RA1220.3.B64 2007 AWBERC Library/Cincinnati,OH 08/29/2008
ELDM  RA1220.3.B64 2007 CCTE/GLTED Library/Duluth,MN 12/06/2010
Edition 2nd ed.
Collation 399 p. : ill. ; 25 cm.
Includes bibliographical references and index.
Contents Notes
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.