Record Display for the EPA National Library Catalog


Main Title Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets /
Author Boelsterli, Urs A.,
Publisher Taylor & Francis,
Year Published 2003
OCLC Number 50002578
ISBN 0415284589; 9780415284585; 0415284597; 9780415284592
Subjects Molecular toxicology. ; Toxicology--methods. ; Xenobiotics--toxicity. ; Xenobiotics--pharmacokinetics. ; Signal Transduction. ; Molecular Biology. ; Toxicologie. ; Chemische stoffen. ; Biomoleculen. ; Toxicologie molculaire.
Internet Access
Description Access URL
Publisher description
Library Call Number Additional Info Location Last
EKBM  RA1220.3.B64 2003 Research Triangle Park Library/RTP, NC 06/24/2005
EKCM  RA1220.3.B64 2003 CEMM/GEMMD Library/Gulf Breeze,FL 05/21/2019
Collation xxiv, 314 pages : illustrations ; 25 cm
Includes bibliographical references and index.
Contents Notes
Introduction -- Types of toxic responses -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Interactions of xenobiotics with ion transporters -- Nuclear receptor-mediated toxicity -- Activation or disruption of cellular signal transduction by xenobiotics -- Disruption of mitochondrial function and mitochondria-mediated toxicity -- Novel mechanisms derived from systems toxicology.