Record Display for the EPA National Library Catalog


Main Title Studies on the Mechanism of Action of Chloroform Stimulation of Rat Hepatic Ornithine Decarboxylase (ODC) (Journal Version).
Author Savage, R. E. ; DeAngelo, A. B. ; Guion, C. ; Pereira, M. A. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC.
Publisher c1987
Year Published 1987
Report Number EPA/600/J-87/374;
Stock Number PB89-106850
Additional Subjects Toxicity ; Chloroform ; Ornithine decarboxylase ; Toxic substances ; Enzyme induction ; Liver ; Laboratory animals ; Sex factors ; Metabolism ; Chlorine organic compounds ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB89-106850 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 19p
It was previously reported that chloroform is a very potent stimulator of rat hepatic ornithine decarboxylase (ODC) activity. In an attempt to more thoroughly understand the mechanism of the stimulation, the effects of a series of pharmacologic, physiologic and toxicologic manipulations on the chloroform response were examined. These studies involved: in vivo experiments in which animals were pretreated with compounds known to affect the various physiological systems and then challenged with chloroform and in vitro experiments in which chloroform was added to the incubation media with/without the compound of interest. The results did not allow the assignment of a specific effect of any of the manipulations to the mechanism of the chloroform response, although much data of significant interest evolved. (Copyright (c) 1987 by PJD Publications Ltd.)