Record Display for the EPA National Library CatalogRECORD NUMBER: 5 OF 8
|Main Title||Neurobehavioral Methods Used in Neurotoxicological Research.|
|Author||Tilson, H. A. ;|
|CORP Author||Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div.|
|Additional Subjects||Nervous system ; Behavioral symptoms ; Toxicology ; Toxicity ; Dose-response relationships ; Neurotoxins ; Environmental pollutants ; Motor activity ; Sensory thresholds ; Risk assessment ; Reprints ; Neurotoxicology ; Tier testing ; Cognitive functions ; Sensory functions|
Behavioral endpoints are being used with greater frequency in the hazard identification phase of neurotoxicology risk assessment. One reason behavioral procedures are used in animal neurotoxicology studies is that they evaluate neurobiological functions known to be affected in humans exposed to neurotoxic agents, including alterations in senory, motor, autonomic and cognitive function. In hazard identification, behavioral tests are used in a tier-testing context. Tests in the first tier are designed to determine the presence of neurotoxicity. Second tier tests are used to characterize neurotoxicant-induced effects on sensory, motor and cognitive function.