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Main Title Interlaboratory Comparison of Motor Activity Experiments: Implications for Neurotoxicological Assessments.
Author Crofton, K. M. ; Howard, J. L. ; Moser, V. C. ; Gill, M. W. ; Reiter, L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Burroughs Wellcome Co., Research Triangle Park, NC. ;National Inst. of Environmental Health Sciences, Research Triangle Park, NC. Lab. of Molecular and Integrative Neuroscience. ;Northrop Services, Inc., Research Triangle Park, NC. ;Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.
Publisher c1991
Year Published 1991
Report Number EPA/600/J-92/019;
Stock Number PB92-143916
Additional Subjects Toxicity ; Nervous system ; Interlaboratory comparisons ; Motor activity ; Risk assessment ; Rats ; Dose-response relationships ; Amphetamines ; Scopolamine ; Carbaryl ; Chlorpromazine ; Endosulfan ; Physostigmine ; Reprints ; Habituation ; Triadimefon ; Cypermethin ; Methylscopolamine
Library Call Number Additional Info Location Last
NTIS  PB92-143916 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 13p
Due to the increasing use of motor activity in neurotoxicology, a major question concerns the potential for differences in experimental findings due to variations in sensitivity and reliability between different laboratories and devices used to measure motor activity. The study addressed the question by examining historical data from a number of laboratories that employed different devices and experimental protocols to measure motor activity. Four aspects of the motor activity data were compared: (1) within laboratory control variability; (2) within laboratory replicability of control data; (3) between laboratory variability in the effects of chemicals; and (4) between laboratory comparison of the control rates of habituation. The analyses indicated that there was a relatively restricted range of within-laboratory variability and reliability in control values, and that these ranges were comparable across laboratories. Similar profiles of habituation were also seen across the different laboratories. Moreover, in virtually every case all laboratories were capable of detecting qualitatively similar changes in motor activity following acute exposure to a variety of chemicals. These data indicate a high degree of comparability in the data generated by the different devices and experimental protocols.