| Main Title |
Carcinogenic N-Hydroxylaminopurine Derivatives Do Not Act as Base Analog Mutagens in 'Salmonella typhimurium'. |
| Author |
McCartney, M. ;
McCoy, E. C. ;
Rosenkranz, H. S. ;
Giner-Sorolla, A. ;
|
| CORP Author |
Case Western Reserve Univ., Cleveland, OH. ;University of South Florida, Tampa. Coll. of Medicine.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1985 |
| Report Number |
EPA-R-809231; EPA/600/J-85/367; |
| Stock Number |
PB86-188216 |
| Additional Subjects |
Bacteria ;
Toxicology ;
Mutagens ;
Reprints ;
Carcinogenesis ;
Salmonella typhimurium ;
Aminopurine/hydroxyl
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-188216 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
10p |
| Abstract |
N-hydroxylaminopurines are highly mutagenic for growing as well as resting Salmonella typhimurium strain TA100 and to a lesser extent for strain TA98. Aminopurines, under similar conditions, are not mutagenic. N-methylhydroxylaminopurine, under similar conditions, exhibits only minimal activity. The results are taken to indicate that unlike non-hydroxylated aminopurines, N-hydroxylaminopurines exert their mutagenicity not by acting as base analogs but by direct covalent binding with DNA-guanine. |
