| Main Title |
Esterification of Arylhydroxylamines: Evidence for a Specific Gene Product in Mutagenesis. |
| Author |
McCoy, E. C. ;
McCoy, G. D. ;
Rosenkranz, H. S. ;
|
| CORP Author |
Case Western Reserve Univ., Cleveland, OH.;Health Effects Research Lab., Research Triangle Park, NC. |
| Year Published |
1982 |
| Report Number |
EPA/600/J-82/459; |
| Stock Number |
PB86-185170 |
| Additional Subjects |
Toxicology ;
Bacteria ;
Polycyclic aromatic hydrocarbons ;
Reprints ;
Mutagenesis ;
Nitroarenes ;
Salmonella typhimurium
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB86-185170 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
9p |
| Abstract |
Characterization of a Salmonella typhimurium mutant strain (TA98/1,8-DNP6) resistant to the mutagenicity of nitrated polycyclic aromatic hydrocarbons (nitroarenes) revealed that it was also non-responsive to the mutagenic action of nitroso- and N-hydroxylaminoarenes. The mutant strain was fully sensitive to the mutagenic action of the corresponding hydroxamic acid ester. These results suggest that TA98/1,8-DNP6 is deficient in a specific esterifying enzyme and that esterification of the penultimate mutagenic metabolites of nitro- and aminoarenes (e.g., arylhydroxylamines) to form potent electrophiles is controlled by a specific gene. |
