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RECORD NUMBER: 109 OF 128

Main Title Results of the IPCS Collaborative Study on Complex Mixtures.
Author Claxton, L. D. ; Creason, J. ; Leroux, B. ; Agurell, E. ; Bagley, S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Health and Welfare Canada, Ottawa (Ontario). Environmental Health Centre. ;Stockholm Univ. (Sweden). ;McMaster Univ., Hamilton (Ontario). ;Laboratoire d'Hygiene de la Ville de Paris (France).
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/058;
Stock Number PB92-150721
Additional Subjects Mixtures ; Toxic substances ; Mutagenicity tests ; Interlaboratory comparisons ; Bioassay ; Environmental pollutants ; Air pollutants ; Tables(Data) ; Salmonella typhimurium ; Benzo(a)pyrene ; Coal tar ; Diesel fuels ; Reprints ;
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NTIS  PB92-150721 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 12p
Abstract
The International Program on Chemical Safety (IPCS) sponsored a collaborative study to examine the intra- and interlaboratory variation associated with the preparation and bioassay of complex chemical mixtures. The mixtures selected were National Institute of Standards and Technology (NIST) Standard Reference Materials (SRM). Twenty laboratories worldwide participated in the study. The participating laboratories extracted the organic portion of two particulate samples--an air particulate sample and a diesel particulate sample--and bioassayed the extracts. The laboratories simultaneously bioassayed a NIST-prepared extract of coal tar and two control compounds (benzo(a)pyrene, and 1-nitropyrene). The bioassay method used was the Salmonella/mammalian microsome plate-incorporation test using strains TA98 and TA100. Study design also allowed for a comparison of sonication and Soxhlet extraction techniques. The particulates samples were mutagenic in both strains with and without activation in all twenty laboratories. The paper provides a complete summary of the data collected during the collaborative study.