Record Display for the EPA National Library Catalog


Main Title Evaluation of neonate squirrel monkeys receiving tritiated water throughout gestation /
Author Jones, David C. L.
Publisher U.S. Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratory,
Year Published 1978
Report Number EPA-600/1-78-004; EPA-68-02-2280
Stock Number PB-276 819
OCLC Number 42838554
Subjects Radiation chemistry--Research ; Squirrel monkeys--Physiology
Additional Subjects Tritium ; Pregnancy ; Radiation effects ; Radiobiology ; Radioactive isotopes ; Infants ; Evaluation ; Laboratory animals ; Monkeys ; Bioassay ; Sex ; Pathology ; Histology ; Concentration(Composition) ; Body fluids ; Body weight ; Radioactivity ; Blood chemical analysis ; Hematology ; Potable water ; Tissues(Biology) ; Tables(Data) ; Primates ; Saimiri sciureus ; Squirrel monkeys ; Toxic substances
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EJBD  EPA 600-1-78-004 c.1 Headquarters Library/Washington,DC 05/19/2014
ELBD ARCHIVE EPA 600-1-78-004 Received from HQ AWBERC Library/Cincinnati,OH 10/04/2023
ELBD RPS EPA 600-1-78-004 repository copy AWBERC Library/Cincinnati,OH 11/03/2014
NTIS  PB-276 819 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation vii, 58 p. : ill. ; 28 cm.
The effect of receiving tritiated water (HTO) throughout gestation on the developing primate was assessed by administering HTO to adult female squirrel monkeys (Saimiri sciureus) as the only source of drinking water beginning with the day of insemination and continuing throughout pregnancy. For the control (tap water) and six experimental groups, the mean urinary tritium concentrations in females delivering full-term progeny were <0.004, 0.05, 0.16, 0.33, 0.75, 1.61, and 3.09 microcuries/ml. Positive bioassays for pregnancy were observed in about half of 277 inseminated females. Among pregnant females, the full-term delivery rate was 36%, the abortion rate was 7%, and the resorption rate was 58% with no discernible effect of HTO administration on any of these parameters. The 46 full-term progeny were evaluated within 2 days of birth. No effects of HTO administration were observed in terms of gestation period (median 153 days, range 141-158 days), sex distribution, body weight, body dimensions, selected organ weights, histology (except gonads), or hematologic pattern. The number of primary oocytes in female progeny decreased markedly within increasing concentrations of tritium. Specific quantification of this effect and evaluation of the neonate testes is in progress.
"EPA-600/1-78-004." "January 1978." Includes bibliographical references (p. 56-57).