Geopolitical overview and juridical aspects -- Geopolitical Overview: Safety and Security in Western and Eastern Europe with Particular Reference to New Trends. Highlighting New Threats and an Innovative Approach to the Necessary Regional Knowledge Management Systems -- A Legal Framework on Dangerous Substances: An International, European and National Perspective -- Territorial Vulnerability in Safety and Security -- Risk: prevention, management and models -- Decision Support System for Crisis Management Planning -- The PRIM (Integrated Regional Programme for Risk Assessment and Management) by Lombardy Region -- The Prim Programme: A Regional Plan for Integrated Risk Assessment and Management -- How Can Risks be Managed in Logistics Networks -- Logistic Plan for Transportation of Dangerous Material in Lombardy Region -- Case study: dangerous substances, monitoring methodologies and integrated risk -- Transport of Packages with Radioactive Material and Spent High Activity Radioactive Sources in Albania (A Case Study) -- Crisis Management During Accident with High Radioactive Sources in Albania -- Emergency Response in Case of an Accident During Transport of Radioactive Materials -- Some Aspects Related to Control of Nuclear Materials - Internal and Transfrontier Cases - in Romania -- Integrated Risk Area Planning: The case of Milan Metropolitan Area -- Conclusions. We are living in a period of major structural and political transitions. The Post-Cold-War world has overcome the barriers, unifying Europe, sorting out Balkan situation, enlarging NATO and the EU; but, at the same time, it has shifted from a simple scenario to a more complex and unpredictable globalized context. In fact, many people wonder whether the world was more secure in the past than it is today or whether this is merely a matter of psychological perceptions. This publication is willing to answer to this question, by connecting the concepts of security and safety, focusing particularly on the transportation of dangerous materials, how to avoid the risks they pose, and how to deal with any problems that do arise.