||Effect of Dibutylnitrosamine and Saccharin on Glutamyl Transpeptidase-Positive Foci and Liver Cancer.
Pereira, M. A. ;
Herren, S. L. ;
Britt, A. L. ;
||Health Effects Research Lab., Cincinnati, OH. ;Cincinnati Univ., OH. Coll. of Medicine.
Malignant neoplasms ;
Antineoplastic agents ;
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An attempt was made to evaluate whether the simultaneous administration of the urinary bladder tumor promoter, saccharin, and the substance being tested for carcinogenicity could be developed into a rapid and efficient bioassay for bladder carcinogens. Dibutylnitrosamine (DBN) a bladder and-to a lesser extent-liver carcinogen, was used as the test substance. The attempted evaluation failed because of the high incidence of liver cancer in the rats that simultaneously received DBN and saccharin.