Record Display for the EPA National Library Catalog


Main Title Rotavirus Fecal IgA Antibody Response in Adults Challenged with Human Rotavirus.
Author Bernstein, D. I. ; Ziegler, J. M. ; Ward., R. L. ;
CORP Author James N. Gamble Inst. of Medical Research, Cincinnati, OH.;Health Effects Research Lab., Research Triangle Park, NC.
Publisher c1986
Year Published 1986
Report Number EPA-R-810341; EPA/600/J-86/551;
Stock Number PB91-117622
Additional Subjects Feces ; Adults ; Human ; Reprints ; IgA ; Rotaviruses ; Viral antibodies ; Rotavirus infections ; Enzyme-linked immunosorbent assay
Library Call Number Additional Info Location Last
NTIS  PB91-117622 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 10p
Studies of rotavirus challenge in adult volunteers made it possible to evaluate the relationship of preexisting anti-rotavirus fecal IgA antibody to infection and illness and to investigate the local response to this infection. No relationship could be found between the preexisting levels of fecal anti-rotavirus IgA antibody and protection from infection or illness. A > 6-fold increase in the level of antibody was seen in 16/19 infected volunteers with determinable increases but not in 0/15 controls who received less than the minimal infectious dose of rotavirus. Antibody levels increased rapidly in infected volunteers and were consistent with an anamnestic response. Two of seven volunteers who received an infectious dose of rotavirus but were considered uninfected on the basis of other laboratory methods had greater than or equal to 6-fold rises of fecal antibody and one of these experienced symptoms compatible with a rotavirus infection. This finding indicates that an increase in fecal antibody may be a reliable indicator of rotavirus infection even in the absence of detectable shedding or seroconversion. (Copyright (c) 1986 Alan R. Liss, Inc.)