Record Display for the EPA National Library Catalog


Main Title Usefulness of the self-fertilizing cyprinodontid fish, rivulus marmoratus as an experimental animal in studies involving carcinogenesis, teratogenesis and mutagenesis /
Author Koenig, Christopher C. ; Abel, Daniel C. ; Klingensmith, Courtney W. ; Maddock, Michael B. ;
Other Authors
Author Title of a Work
Koenig, Christopher C.
Abel, Daniel C.
Klingensmith, Courtney W.
Maddock, Michael B.
CORP Author Charleston Coll., SC. Grice Marine Biological Lab.;Environmental Research Lab., Gulf Breeze, FL.
Publisher U.S. Environmental Protection Agency, Environmental Research Laboratory ;
Year Published 1982
Report Number EPA-600/3-82-075
Stock Number PB82-249194
OCLC Number 1043838067
Subjects Animal experimentation--Caribbean Sea. ; Cyprinodontidae. ; Cancer--Animal models.
Additional Subjects Fishes ; Toxicology ; Minnows ; Bioassay ; Behavior ; Laboratory animals ; Caribbean Sea ; Research ; Carcinogenesis ; Teratogenesis ; Mutagenesis ; Rivulus marmoratus ; Medical research
Internet Access
Description Access URL
Library Call Number Additional Info Location Last
EKCD  EPA-600/3-82-075 CEMM/GEMMD Library/Gulf Breeze,FL 07/17/2018
NTIS  PB82-249194 Some EPA libraries have a fiche copy filed under the call number shown. 07/26/2022
Collation 129 pages : illustrations ; 28 cm
Rivulus marmoratus is a naturally self-fertilizing cyprinodontid fish inhabiting mangrove marshes throughout the Caribbean. As a result of internal self-fertilization this oviparous species is composed of a number of isogenic, homozygous lines (clones), several of which have been identified by histocompatibility experiments and maintained in laboratory culture for over 30 years. Simplified culture and handling methods are given and data are presented on the reproduction, growth and development of rivulus under laboratory culture as a prelude to the evaluation of its potential as a bioassay animal. Several types of bioassays were run and evaluated using rivulus: behavioral, carcinogenicity, teratogenicity, toxicity, and mutagenicity. Advantages and disadvantages of using rivulus for such bioassays are discussed.
Caption title. "Grant No. R805469 Ol" "Project Officer William P. Davis, Bears Bluff Field Station"