The Health and Environmental Effects Profile for benzenamine, 4,4'-methylene bis was prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste to support listings of hazardous constituents of a wide range of waste streams under Section 3001 of the Resource Conservation and Recovery Act (RCRA). Both published literature and information obtained from Agency program office files were evaluated as they pertained to potential human health, aquatic life and environmental effects of hazardous waste constituents. Quantitative estimates have been presented provided sufficient data are available. Benzenamine, 4,4'-methylene bis has been evaluated as a carcinogen. The human carcinogen potency factor (q1*) for benzenamine, 4,4'-methylene bis is .25 (mg/kg bw/day)-1 for oral exposure.

"Prepared by Syracuse Research Corporation under EPA contract no. 68-03-3228." "Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development." "January 1984." "EPA 600-X-84-231." Includes bibliographical references (pages 19-23).

1. Introduction -- 1.1. Structure and CAS number -- 1.2. Physical and chemical properties -- 1.3. Production data -- 1.4. Use data -- 2. Environmental fate and transport processes -- 3. Exposure -- 4. Pharmacokinetics -- 5. Effects -- 5.1. Carcinogenicity -- 5.2. Mutagenicity -- 5.3. Teratogenicity -- 5.4. Other reproductive effects -- 5.5. Chronic toxicity -- 5.6. Other relevant information -- 6. Aquatic toxicity -- 7. Existing guidelines and standards -- 7.1. Humans -- 7.2. Aquatic -- 8. Risk assessment -- 9. References -- Appendix A: literature searched -- Appendix B: derivation of q1* using male rat data -- Appendix C: derivation of q1* using male mouse data -- Appendix D: derivation of q1* using female mouse data.