Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Dopamine Depletion Slows Retinal Transmission.
Author Dyer, Robert S. ; Howell, William E. ; MacPhail, Robert C. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1981
Report Number EPA-600/J-80-014;
Stock Number PB82-127432
Additional Subjects Norepinephrine ; Eye(Anatomy) ; Retina ; Depletion ; Reprints ; Dopamine
Library Call Number Additional Info Location Last
NTIS  PB82-127432 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 17p
In male hooded rats, depletion of norepinephrine and dopamine by a-methyl-paratyrosine (AMT) significantly increased the latencies of early peaks in flash-evoked potentials recorded from the visual cortex, lateral geniculate nucleus, and optic tract. These effects were not produced by depletion of norepinephrine by FLA-63, blockade of muscarinic acetylcholine receptors by scopolamine, or blockade of opiate receptors by naloxone. AMT effects occurred only when flashes were used; optic tract stimulation failed to reveal the drug-induced changes. In a dose-response study, haloperidol produced effects similar to those of AMT. L-Dopa + R04-4602 reversed some of the effects of AMT. It is concluded that depletion of retinal dopamine impairs the timing of retinal responses to light.