Record Display for the EPA National Library Catalog
RECORD NUMBER: 385 OF 2486| Main Title | Comparative potency approach for estimating the cancer risk associated with exposure to mixtures of polycyclic aromatic hydrocarbons (interim report final) {Microfiche} | |||||||||||
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| Author | Lewtas, Joellen | |||||||||||
| CORP Author | ICF-Clement Associates, Fairfax, VA.;Environmental Protection Agency, Washington, DC. Office of Health and Environmental Assessment. | |||||||||||
| Publisher | ICF-Clement Associate for U.S. Environmental Protection Agency | |||||||||||
| Year Published | 1988 | |||||||||||
| Report Number | EPA-68-02-4403; EPA/600/R-95/108 | |||||||||||
| Stock Number | PB95-252847 | |||||||||||
| Subjects | Genetic toxicology--Technique | |||||||||||
| Additional Subjects | Polychloric aromatic hydrocarbons ; Carcinogenesis ; Risk assessment ; Dose-response relationships ; Mathematical models ; Environmental health ; Biological effects ; Concentration(Composition) ; Occupational exposure ; Mixtures ; Potency estimate | |||||||||||
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| Collation | 138 p. ; 28 cm. | |||||||||||
| Abstract | A relative potency approach was developed as a method for assessing the cancer risk of polycyclic aromatic hydrocarbons (PAHs) for which inadequate ingestion or inhalation bioassay data exist. This approach takes into account the differing potencies of carcinogenic PAHs rather than assuming that all carcinogenic PAHs are equivalent in potency to benzo(a)pyrene. A two-stage mathematical dose-response model is postulated that is consistent with the biological mechanisms of action of PAHs. The assumptions for using a two-stage model for PAH carcinogenesis are described and their experimental support presented. |
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| Notes | "EPA 600/R-95/108." |